The OS-related genes were enriched in the cytokine-cytokine receptor interaction pathway, NF-kappa B signaling pathway, JAK-STAT signaling pathway, apoptosis, PI3K-AKT signaling pathway, and MAPK signaling pathway as revealed by the GSEA results, which have been identified by previous studies serving as an important role in the pathogenesis and progression of AML. Here, AKT1 is linked to acute myeloid leukemia.