Some scholars also reported the PI3K/AKT pathway is associated with oxidative stress-mediated survival of melanoma and when targeting the PI3K/AKT and MAPK/ERK signaling pathway exerts an anticancer effect in leukemia cells by induction of oxidative stress and the cellular antioxidant defense mechanisms, which suggest PI3K/AKT and MAPK/ERK signaling pathway might involve in the leukemia cell apoptosis caused by oxidative stress [36, 37]. This evidence concerns the gene AKT1 and melanoma.