To achieve this, the conditional medium of THP-1 with or without hypoxic stimulation was incubated with the GBM cell line LN229 and U251 (Figure 3(a)), and our MTT assay results suggested that hypoxic M2 macrophage conditional medium (M2-CM) significantly increased the proliferation abilities in the GBM cells (Figures 3(b) and 3(c)), which were supported by the Real-Time qPCR analysis results that M2-CM also increased the mRNA levels of CDK2, CDK6, and Cyclin D1 to promote cell mitosis in the GBM cells (Figures 3(d) and 3(e)). Here, CDK2 is linked to glioblastoma.