The results of OS analysis suggest that PDIA3 is a high-risk gene for ACC, CESC, GBM, HNSC, KICH, KIRP, LGG, and UVM, especially KICH (hazard ratio = 1.009), while it is a low-risk gene for LAML and UCEC. This evidence concerns the gene PDIA3 and adrenal cortex carcinoma.