Sporadic and familial ALS brain, spinal cord, sera, and cerebrospinal fluid (CSF) exhibit upregulation of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL6), and interleukin 1β (IL1β) [11–14]. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.