S100A16 is an astrocyte specific protein upregulate in tumors of different origins 102, Study by Szeliga M et al. found that transfection with liver-type glutaminase (LGA) cDNA increased the expression of LGA mRNA and protein and the ability of the cells to degrade glutamine, which result in reduction of survival, migration and proliferation of T98G glioma cells. This evidence concerns the gene GLS2 and central nervous system cancer.