J C Lindsey et al. screened S100 genes for evidence of epigenetic regulation in medulloblastoma through a pharmacological expression reactivation approach, which found that S100A6 upregulated expression in multiple medulloblastoma cell lines after treatment with DNA methyltransferase inhibitor, 5′-aza-2′-deoxycytidine. The gene discussed is S100A6; the disease is medulloblastoma.