Leying Zhang, et al. evaluated the effect of S100B-RAGE function on macrophages/microglia function in a murine glioma model, which found that glioma-mediated activation of STAT3 (signal transduction and activators of transcription 3) in macrophages/microglia might partly occur by the RAGE pathway and low levels of S100B induced STAT3 and inhibited microglia activation. Here, S100B is linked to central nervous system cancer.