For instance, study by Duan L et al. showed that a colorectal carcinoma cell line with relatively high S100A6 expression, leading to the inhibition of cell proliferation, migration and MAPK (mitogen-activated protein kinase) activity, further study suggest that S100A6 promotes the growth and migration by activating ERK1/2 (extracellular regulated protein kinase) and p38/MAPKs in colorectal carcinoma, and modulating of these pathways may be employed for colorectal carcinoma prevention and therapy 46. This evidence concerns the gene WNK2 and colorectal carcinoma.