By integrating the aforementioned parameters, Iida et al. proposed the novel CRP-albumin-lymphocyte (CALLY) index—defined as serum albumin level (g/dL) × absolute lymphocyte count (cells/μL) / CRP level (mg/dL) × 104—and discovered a significant association between low CALLY index and poor overall survival (OS) in those with hepatocellular carcinoma (HCC) after hepatectomy 17. This evidence concerns the gene CRP and hepatocellular carcinoma.