MiRNA-let-7c-5p, the miRNA studied in our research, has been widely reported in different cancer types, it can mediate the pathogenesis progression of NSCLC by targeting ITGB3 and MAP4K3 31, and promote the sensitivity of LUAD cells to EGFR-TKIs by inhibiting the WNT pathway 32. Here, MAP4K3 is linked to cancer.