For example, administration of 25% alcohol (16 weeks) to 3xTg-AD mice impairs cognition and is associated with increased phospho tau (Ser199/202) burden compared to non-alcohol–consuming 3xTg-AD mice (Hoffman et al., 2019) and administration of 4% alcohol to APP/PS1 double transgenic AD mice increases β-amyloid (Gong et al., 2021). This evidence concerns the gene PSEN1 and Alzheimer disease.