APP and Alzheimer disease: Studies in rodents similarly demonstrate that alcohol consumption detrimentally impacts cognitive function, learning, and memory and can alter levels of proteins characteristic of AD including tau, amyloid precursor protein (APP), and presenilin-1 (PSEN-1) in brain regions important for learning and memory, such as the CA1 region of the hippocampus and the basal lateral amygdala (BLA) (Laske et al., 2010; Huang et al., 2018; Hoffman et al., 2019).