IRAK4 and early-onset autosomal dominant Alzheimer disease: Examples include: PROTACs targeting interleukin-1 receptor-associated kinase 4 (IRAK4) for the treatment of autoimmune and inflammatory disease [41]; PROTAC degraders of viral proteins for inhibition of the hepatitis C virus [42]; and Tau degraders for the treatment of Alzheimer’s disease [43, 44].