Other areas of need are preventative or therapeutic treatments for CP caused by PRSS1 gain-of-function mutations, other trypsin-related disorders (e.g., simple and complex genetic variants linked to serine protease inhibitor Kazal-type 1, SPINK1, or Chymotrypsin-C, CTRC), ER stress-related CP, hypertriglyceridemia recurrent acute pancreatitis and others. The gene discussed is SPINK1; the disease is acute pancreatitis.