The top 10 hub target genes of Kangai injection were rated from high to low as TP53, VEGFA, EGFR, TNF, ESR1, STAT3, HSP90AA1, HDAC1, AR, and MMP9. Among the top 10 hub target genes of CRC and Kangai injection, there were 3 identical genes that were TP53, VEGFA, and EGFR in particular. This evidence concerns the gene ESR1 and colorectal carcinoma.