ESR1 and colorectal carcinoma: To further explore the pharmacological mechanism of Kangai injection in the treatment of CRC, we constructed a PPI network based on 114 overlapping genes (Figure 3); the red circles represented the top 10 hub genes which included “TP53 (degree = 57),” “VEGFA (degree = 50),” “EGFR (degree = 49),” “TNF (degree = 43),” “ESR1 (degree = 42),” “STAT3 (degree = 39),” “HSP90AA1 (degree = 36),” “AR (degree = 31),” “HDAC1 (degree = 30),” and “MMP9 (degree = 28).”