The top 10 hub genes included “TP53 (degree = 588),” “AKT1 (degree = 525),” EGFR (degree = 491), “MYC (degree = 487),” “GAPDH (degree = 481),” “VEGFA (degree = 433),” “INS (degree = 417),” “EGF (degree = 403),” “IL6 (degree = 400),” and “PTEN (degree = 392).” The Cytoscape software was used to construct the PPI network of CRC-related top 10 hub genes (Figure S1). Here, INS is linked to colorectal carcinoma.