The research uncovered that the key active ingredients of GJD in managing primary hypertension are puerarin, tanshinone IIA, daidzein, ursolic acid, and cryptotanshinone, which are mainly expected to contain a regulatory function in conjunction with AGTR1, AKT1, EDNRA, MAPK14, MAPK8, and CHRM2. Here, MAPK8 is linked to essential hypertension.