AKT1 and non-small cell lung carcinoma: Besides, EGFRs with its aberrant expression and constitutive activation in in NSCLC [81] stimulate three of the most well-characterized signaling branches such as Ras-MAPK, phosphoinositol 3 kinase (PI3K)-protein kinase B (PKB)/Akt and phospho lipase C (PLC)-PKC pathways, enhancing ER-mitochondria Ca2+ transfer, thereby abolishing mitochondria-induced apoptosis.