ORAI1 and breast carcinoma: Chantôme, et al. [105] once reported that the interaction of Orai1 with SK3 channel, a potassium channel belonging to the small conductance Ca2+-activated potassium (KCa) channel family, regulated the constitutive (Ca2+)e entry through Orai1 localization within the lipid raft, which affected the migratory ability of breast cancer cells.