Concomitantly, downregulation of protein phosphatase and tensin homolog (PTEN) in NSCLC tumors [79] antagonized F-box and leucine rich repeat protein 2 (FBXL2)-induced ubiquitination of IP3R3, thereby stabilizing IP3R3 in ER [80]. Here, ITPR3 is linked to non-small cell lung carcinoma.