The immune phenotype of pleural fluid cells had no prognostic significance, whereas expression of programmed death 1 (PD-1), lymphocyte activating 3 (LAG-3), and T cell immunoglobulin and mucin domain 3 (TIM-3) in tumor-infiltrating lymphocytes (TILs), but not in T cells in pleural effusion, correlated with lower OS [109]. This evidence concerns the gene LAG3 and neoplasm.