Despite Fiorelli et al. [54], observed no significant differences between malignant effusions from lung cancer (n = 11) and mesothelioma (n = 13) in VEGF levels, their data supported the use of this marker in ruling out malignancy in diagnostic work up of pleural effusion, showing that median VEGF level was significantly higher in malignant (n = 49) than that in benign exudates (n = 15). This evidence concerns the gene VEGFA and lung carcinoma.