Osimertinib is a third-generation EGFR-TKI designed to target T790M positive (T790M+) EGFR in patients who have acquired this mechanism of resistance to earlier generation TKIs (phase III AURA3 trial: AZD9291 versus platinum-based doublet-chemotherapy in locally advanced or metastatic non-small cell lung cancer, NCT02151981) [6, 12]. Here, EGFR is linked to non-small cell lung carcinoma.