Also, our group has demonstrated that epithelial-to-mesenchymal transition (EMT) and activation of AXL, Hedgehog and MAPK pathway can co-occur in murine xenografts of EGFR-mutant NSCLC treated with a sequence of first-generation EGFR-TKI, second-generation EGFR-TKI afatinib and osimertinib [31]. Here, EGFR is linked to non-small cell lung carcinoma.