CD274 and neoplasm: Exploratory analyses revealed that higher pre- and on-treatment sTILs and higher pre-treatment PD-L1 expression [based on the combined positive score (CPS), defined as the number of PD-L1 stained cells including tumor cells, lymphocytes, and macrophages/histocytes, divided by the total number of viable tumor cells and multiplied by 100, and assessed using the IHC 22C3 pharmDx assay] were significantly and positively associated with pCR.