Interestingly, in the multicenter phase II GIADA trial (Eudract 2016-004665-10), 43 premenopausal HR+/HER2-luminal B-like BC patients were enrolled to receive, in the neoadjuvant setting, induction anthracycline-based chemotherapy followed by the combination of endocrine therapy (ovarian-function suppression + aromatase inhibitor) plus the anti-PD1 agent Nivolumab [41]. Here, ERBB2 is linked to breast cancer.