A fusion protein generated by chromosomal translocation in AML. The fusion protein comprises of conserved runt homology (which is the DNA binding domain) from the hematopoietic TF RUNX1 (also known as AML1) and ETO repressor protein. It is considered as a transcriptional repressor of all RUNX1 target genes. This evidence concerns the gene TF and acute myeloid leukemia.