Taking into account of our resultsevidencing not only the anti-apoptotic function of Bcl2L10 but also its role inpromoting in vitro melanoma cell migration, invasion, and VMthrough the involvement of MMPs and uPAR, we can suggest that Bcl2L10 should beconsidered in the evaluation of novel anti-apoptotic Bcl-2 protein inhibitors andcould represent a potential target for the treatment of melanoma. The gene discussed is BCL2L10; the disease is melanoma.