BCL2 and melanoma: They are expressed in normal melanocytes and are frequentlyderegulated in melanoma [2].Previously studies found that both Bcl-2 and Bcl-xL, antiapoptotic members of theBcl-2 family, were associated with melanoma progression, resistance to apoptosis,and poor prognosis by acting on processes, such as cell proliferation, migration,invasion, and activating crosstalk with the tumor microenvironment [2–4].