Thus, the role of Bcl-2 proteinsin regulating intracellular and mitochondrial Ca2+ homeostasis,and subsequently to several other processes such as cell migration, independently ofapoptosis, is emerging [53].Increased intracellular Ca2+ levels have been described to beassociated to the anti-migration effects of alkaloid compounds in liver cancer cells[54]. This evidence concerns the gene BCL2 and liver cancer.