Several cellularpathways were described to be activated during melanoma progression, such as ratsarcoma (RAS)/v-raf murine sarcoma viral oncogene homolog B1(BRAF)/mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase(PI3K)/AKT, have been reported to promote or downregulate different B-celllymphoma-2 (Bcl-2) family molecules. The gene discussed is BCL2; the disease is melanoma.