Knockdown of the FANCI protein, which functions alongside FANCD2 in the FANCD2/FANCI complex, has been associated with enhanced cisplatin sensitivity in amoeba [87], although only limited studies of its role in cancer have been performed to date, with one study linking it to an aggressive phenotype in pancreatic cancer [114]. This evidence concerns the gene FANCD2 and familial pancreatic carcinoma.