A more recent cell based chemical library screen showed that the cardiac glycoside Ouabain, used to treat heart failure and previously reported to reduce proliferation in various cancer cell lines, also inhibits monoubiquitylation of FANCD2 and sensitizes cells to mitomycin C through a p38 dependent mechanism, although the dependence of this on the FA pathway has not been demonstrated [150]. The gene discussed is FANCA; the disease is cancer.