METTL1 and cancer: Ma et al. (2021) reported that METTL1 and WDR4, which are components of m7G methyltransferase, exhibited an increase in expression in lung cancer tissues compared with normal tissues, which was associated with poor prognosis. However, knockout of METTL1 and WDR4 decreased the potential of cancer cells in proliferation, invasion, and oncogenesis. Another study found that METTL1 advanced the translation of VEGFA mRNA dependent on m7G methylation, resulting in increased angiogenesis (Zhao et al., 2021).