RNA binding protein genes such as PTBP1, PPIH, SMAD5, MSI2, RBM15, MRPS17, and ADAT3 were identified to be prognosis-related in STAD patients, the regulatory network and functional study showed MRPS17 and PTBP1 could reduce the number of infiltrated immune cells. This evidence concerns the gene PTBP1 and gastric adenocarcinoma.