A landscape of the tumor immune microenvironment derived from immunogenomics data classified BRCA into 5 immune subtypes: C1 (wound healing), C2 (IFN-g dominant), C3 (inflammatory), C4 (lymphocyte depleted) and C6 (TGF-b dominant) (Thorsson et al., 2018). This evidence concerns the gene TGFB1 and neoplasm.