TMPRSS2 was found to favor the immune escape of COVID-19 (Shang et al., 2020), and TMPRSS4 was upregulated in malignancies of the stomach (Tazawa et al., 2022), liver (Dong et al., 2020), and prostate (Lee et al., 2021). The gene discussed is TMPRSS2; the disease is COVID-19.