For example, Hsp72 has been previously reported to promote the oxaliplatin resistance of GC cells by inhibiting SDF-2 degradation (Takahashi et al., 2016); Hsp90ab1 is known to facilitate the epithelial–mesenchymal transition in GC by preventing LRP5 ubiquitination (Wang et al., 2019). Here, LRP5 is linked to gastric cancer.