The risks factors that can predispose to ICI-induced hepatotoxicity are: underlying chronic liver disease [62], high dose of ipilimumab (10 mg/kg) [28], the use of CTLA-4 inhibitors or combination therapy [64, 65], the presence of other irAEs [66], liver metastases [62] and underlying autoimmune disorders such as thyroiditis or rheumatological disorders [67]. Here, CTLA4 is linked to autoimmune disease.