NFE2L2 and cancer: Further, analysis of ERL treated rat hepatocellular carcinoma and NSCLC patient tissue microarray data [43, 45] confirmed our observed perturbations in NRF2 network by exhibiting similar trend patterns and concomitant directional expression of NRF2 and HER4 (Figure 4D) as with the ovarian (Figure 4A and B) and lung (Figure 4C) cancer cell lines.