Meanwhile, emerging evidence has suggested that palmitic acid but not myristic or stearic acid exerts adverse effects on ER function by stimulating stress signaling XBP1 and ATF6 (82), which may play a pivotal role in arresting the cell cycle progression in islet (83) and initiating a positive feedback loop in production of even-chain SFAs via de novo lipogenesis (84), ultimately contributes to the occurrence of metabolic diseases. The gene discussed is ATF6; the disease is metabolic disease.