Other Ca2+-toolkit proteins implicated in various cancers include calcineurin, SERCA pumps, SPCAs, PMCAs, the IP3R, RyRs, STIM proteins, T-Type VGCCs, TRPC1, TRPC3, TRPC6, TRP ion channel melastatin 2 (TRPM2), TRPM7 and TRPM8 [15, 17, 34]. The gene discussed is TRPM8; the disease is cancer.