Some Ca2+-permeable channels have been implicated in the enhanced migration of various cancers: TRPC1, TRPM7, TRPM8, TRPV1, TRPV2, TRPV6, STIM1, Ca2+-release activated Ca2+ modulator 1 (Orai1) and some types of VGCCs [17, 33]. The gene discussed is TRPM8; the disease is cancer.