Maeda et al. [50] established a pathway for TRPM5-mediated, lung metastasis in a murine melanoma cell line: following activation by EA, TRPM5 increased [Ca2+]c; this, in turn, activated nuclear factor kB (NF-kB) which subsequently increased the expression of matrix metalloproteinase-9. This evidence concerns the gene NFKB1 and melanoma.