NFATC2 and colorectal cancer: Zhou et al. [138] examined the molecular effects of ACCN1, 2, 3, and 4 and noted that only ASIC2 (encoded by ACCN1) promoted invasion and metastasis of colorectal cancer, under acidosis; such metastasis was achieved by the activation of the calcineurin/NFAT1 axis [8].