CD274 and serous adenocarcinoma: In this setting, the KEYNOTE-028 phase Ib trial included a small SGC cohort of 28 PD-L1 positive patients treated with P. The response was primarily observed in histotypes with a high PD-L1 expression, and higher mutational load, 3 PRs (11.5%) have been reported in two adenocarcinomas nitric oxide synthase (NOS) and one case of high-grade serous carcinoma [102].