Considering coding genes, the number of differentially expressed transcripts was greater after MZ1 than after birabresib (MZ1 n = 885, birabresib n = 213; P = 0.0001, one tail Fisher’s exact test), indicating that the BET degrader MZ1 had a bigger impact on the transcriptome of ABC DLBCL than the BET inhibitor birabresib. Here, DNER is linked to diffuse large B-cell lymphoma.