ABC and GCB DLBCL show different gene expression profiles and display specific oncogenic pathway perturbations, such as a constitutively active nuclear factor kappa B (NF-κB) and Janus tyrosine kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signaling in the ABC subtype [2, 3]. The gene discussed is STAT3; the disease is aneurysmal bone cyst.