Genomic studies using SNP arrays, high-density CGH arrays, WGS and WES on several large patient cohorts identified a set of frequently mutated genes in MM, some of them belonging to NF-κB pathway: TP53, KRAS, NRAS, BRAF, MAX, FAM46C, DIS3, IRF4, HIST1H1E, EGR1, LTB, FGFR3, TRAF3, CYLD, and RB1. This evidence concerns the gene IRF4 and Miyoshi myopathy.