POLE and neoplasm: According to the Tumor Cancer Genome Atlas (TCGA) classification, EC subtypes with high tumor mutational burden, POLE mutant and microsatellite instability hypermutated (MSI-H) with a deficiency in the mismatch repair system (dMMR), are highly immunogenic: that is, they exhibit elevated tumor specific neoantigens, resulting in an enlarged number of CD3+ and CD8+ TILs and in a compensatory up regulation of immune checkpoints [27].