The rationale for combining immunotherapy with antiangiogenic agents lies on the ability of the latter to enhance T cell trafficking and infiltration into the tumor microenvironment [64]: in preclinical models, the inhibition of vascular endothelial growth factor (VEGF) signaling promoted antitumor immunity and enhanced the efficacy of immune checkpoint blockade [65], moreover the combination of anti-VEGF and anti-PD-L1 showed a synergistic anti-tumor effect in vivo [66]. This evidence concerns the gene CD274 and neoplasm.