Beside the previously described mechanism for SCLC by which chemotherapy can broadly activate the immune system, an in vitro study investigated the effect of cisplatin, oxaliplatin and pemetrexed on three different MPM cells lines and highlighted a potential downregulation effect of cisplatin on immune checkpoints expression (PD-1, LAG-3, TIM-3) suggesting that this chemotherapeutic agent might be a promising partner for ICIs also in MPM [87]. The gene discussed is PDCD1; the disease is small cell lung carcinoma.