Different EGFR tyrosine kinase inhibitors (TKIs) can be used in advanced NSCLC: gefitinib, erlotinib, afatinib, dacomitinib, and osimertinib are indicated for patients with EGFR activating mutations, while erlotinib has been approved also for patients with EGFR wild type (WT) tumors pretreated with first- or second-line therapy [10–13]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.