EGFR and non-small cell lung carcinoma: Several clinical trials evaluated the activity of the dual inhibition of angiogenesis and EGFR in NSCLC patients with EGFR mutation, including combination of erlotinib plus bevacizumab, gefitinib plus bevacizumab, afatinib plus bevacizumab, erlotinib plus ramucirumab (Table 3).