Sorafenib is a small molecule targeting VEGFR-2 and VEGFR-3, rapidly accelerated fibrosarcoma (Raf), rearranged during transfection (RET), tyrosine-protein kinase KIT, FMS-like tyrosine kinase 3 (FLT-3), and PDGFR-β, with limited anti-tumor activity in NSCLC when used as a single-agent [27–28]. The gene discussed is RET; the disease is non-small cell lung carcinoma.