Positive correlation between FADS1 expression and increased macrophage infiltration was of note particularly in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), pancreatic adenocarcinoma (PAAD), and pheochromocytoma and paraganglioma (PCPG) cancer types with significant correlation demonstrated with all three EPIC, TIMER and XCELL algorithms. The gene discussed is FADS1; the disease is hereditary pheochromocytoma-paraganglioma.