Univariable Kaplan-Meier analyses showed that high FADS1 expression is associated with worse OS (HR=1.610; 95% CI 1.236-2.098; p<0.001) and DFS (HR=1.653; 95% CI 1.236-2.213; p<0.001) for renal cell carcinoma patients (KIRC, KIRP and KICH) (Figure 2A), whereas better OS (HR=0.537; 95% CI 0.419-0.687; p<0.001) and DFS (HR=0.532; 95% CI 0.418-0.678; p<0.001) for brain tumor patients (LGG and GBM) (Figure 2B). The gene discussed is FADS1; the disease is hereditary clear cell renal cell carcinoma.