IGF1R and central nervous system cancer: Studies have revealed that several regulators take part in anoikis resistance in glioma; these include integrin, E-cadherin, EGFR, IGFR, Trk, TGF-β, the Hippo pathway, NF-κB, eEF-2 kinase, MOB2, hypoxia, acidosis, reactive oxygen species (ROS), heat shock proteins (Hsps) and protective autophagy.