In this case, neuroinflammation is triggered by disease-specific neurogenerative burdens, such as the accumulation of intracellular aggregates (e.g. hyper-phosphorylated Tau in AD, RNA granules in ALS, and Lewy body in PD) or extracellular plaques, such as amyloid plaques. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.