The latest study confirmed that exosomal miR-29b-3p can regulate cellular insulin sensitivity via sirtuin- (SIRT-) 1 (Figure 2) [14], which is a class III histone deacetylase deeply involved in apoptosis, genomic stability, and gene expression regulation, indicating that histone modification related to insulin resistance is one of the treatment approaches of MSCs. This evidence concerns the gene INS and Insulin resistance.