GPT and type 2 diabetes mellitus: In 2012, Ezquer et al. found that intravenously transplanted MSCs could significantly lower a panel of disordered biochemical markers of liver function caused by HFD, for instance, alkaline phosphatase (AKP), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), implying that MSCs could improve liver function of T2DM patients (Figure 1) [18].