Interstitial lung disease was seen in one (5.6%) patient with no antibodies, corresponding to non-specific interstitial pneumonia, and in four (22.2%) seropositive patients, as follows: two had non-specific interstitial pneumonia (one with positive anti-Ro52, one with anti-MDA5 + anti-Jo1 + anti-TIF1ɣ), one had usual interstitial pneumonia and presented with positive anti-cN1A + anti-Ro52, and one had an unclassified ILD and presented with positive anti-MDA5 + anti-SAE1 + anti-NXP2 (Table 3). This evidence concerns the gene TRIM21 and interstitial lung disease.