• Tumor cells secrete FGF, PDGF, SDF→ ↑CAF→ ↑PDGF, TGF-β→ ↑tumor growth • CAF→ immunosuppression via TGF-β • CAF→ ↑angiogenesis via VEGF, CXCL12 • CAF→ ↑MDSC recruitment via CCL7 • CAF→ glucosaminoglycans and MMP-2→ ↑tumor migration. The gene discussed is MMP2; the disease is neoplasm.