• M2 produce IL-10→ induce PD-L1 on monocyte→ ↑infiltration of Treg and ↓CTL • M2→ ↑PD-1→ ↓macrophage phagocytosis via tumor PD-L1 • M2→ ↑PD-L2→ immune escape and tumor promotion via PD-1 • M2→ ↑tumor growth via EGF, FGF, PDGF, IL-4 • M2→ ↑angiogenesis via VEFG, IL-8, FGF, MMP-9. The gene discussed is EGF; the disease is neoplasm.