• N1 TANs kill tumor cells via ADCC and pro-inflammatory factors (IFN-γ, MMP-8) & ROS • N1 TAN recruit DC via CCL19, CCL20 and T cells via CXCL9, CXCL10 and stimulate CTL, NK via TNF-α. Here, CXCL9 is linked to neoplasm.