TNF and neoplasm: • DC as APC and stimulate CTL via ICAM-1, CD86, CD40, CD80 • DC recruit naïve T cell via CCL17, CCL19, CCL22, IL-32 • DC stimulate Th1, CTL, NK via IL-12, IL-15 • DC→ ↑Ag expression by tumor via TNF-α, IL-6