CAFs then reciprocally promote tumor progression by production of growth factors (PDGF, TGF-β, epidermal growth factor (EGF), bone morphogenetic proteins (BMP) and C-X-C motif chemokine 12 (CXCL12), CXCL13) and these cells also stimulate angiogenesis by secreting vascular endothelial growth factor (VEGF), CXCL12 and FGF2 (72–75). The gene discussed is EGF; the disease is neoplasm.