IGF2 and Hypoglycemia: Non-Islet Cell Tumor Hypoglycemia (NICTH) is a paraneoplastic syndrome where non-endocrine tumors cause hypoglycemia, while promoting anabolism of tumor cells by aberrantly producing insulin-like growth factor II (IGF-II), insulin receptor antibodies and various cytokines (tumor necrosis factor-α, interleukin-1 and−6) (142–145).