Prior studies have shown that multiparous mouse mammary tumor virus (MMTV)-RANK mice, with RANK OE in the mammary gland under MMTV, develop spontaneous breast tumors with long latency and only after multiple pregnancies [126], although tumor latency decreases and tumor incidence increases compared to wild-type after carcinogenic protocols [22, 115]. This evidence concerns the gene TNFRSF11A and breast neoplasm.