Genetic or pharmacological inhibition of RANK signaling abrogated carcinogenesis in this model and also delayed tumor onset and decreased tumor and metastases incidence in HER2+ or polyomavirus-induced BC, MMTV-Neu, and MMTV-polyomavirus middle T antigen (PyMT) mice [127, 128]. This evidence concerns the gene TNFRSF11A and breast cancer.