In the last decade, extensive research stemming from the observation of RANK-expressing RANKL-sensitive cancer cell lines from different tumor types, including BC [110–113], clearly corroborated that the RANKL-RANK pathway is a major mediator of breast physiology and carcinogenesis [107, 114–116] as recently reviewed by our study group [117]. The gene discussed is TNFSF11; the disease is cancer.