Cyclin-dependent kinase (CDK) inhibitors such as flavopiridol is one such class of compounds that has been shown to potently downregulate Mcl-1 expression in B-cell chronic lymphocytic leukemia (CLL) that resulted in patients with high risk and refractory CLL [93, 94]. The gene discussed is MCL1; the disease is B-cell chronic lymphocytic leukemia.