MCL1 and neoplasm: For enhanced biosynthesis of Mcl-1 protein, tumor cells rely on chromosomal alterations that allow increased transcription of the Mcl-1 gene such as through increased accessibility of its promoter [22], increased gene dosage through chromosomal translocation events that involve the Mcl-1 gene [23, 24], enhanced translation of the Mcl-1 messenger RNA (mRNA) [25] and increased stabilization of Mcl-1 mRNA by regulation of microRNAs (miRNAs) targeting it [26–28].