Furthermore, in a mouse model of cerulein-induced pancreatitis, the use of the TRPV1 antagonist capsazepine inhibited primary sensory neurons and reduced tissue inflammation, thereby inhibiting the release of SP and the subsequent NK1R activation, eventually alleviating the severity of fibrosis in the pancreas (Nathan et al., 2001; Hutter et al., 2005). The gene discussed is TACR1; the disease is pancreatitis.