Hypertension induced by deoxycorticosterone acetate salts (DOCA) causes glomerulosclerosis, increases the number of proliferating cell nuclear antigen (PCNA)-positive tubular cells, tubular interstitial fibrosis, and ECM over-deposition in both wild-type and TRPV1-/- mice; however, TRPV1-/- mice exhibit more severe symptoms than wild-type mice (Wang et al., 2008). Here, PCNA is linked to hypertensive disorder.