Histopathologic findings in AD patients’ brains usually occur much earlier than clinical manifestations of the disease; they include β-amyloid deposition in the interneural space and accumulation of abnormal, hyperphosphorylated tau proteins within neurons (Sperling et al., 2011; Kumar et al., 2015; Hanseeuw et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.