In addition, they regulate many AD-associated processes, including APP processing, tau protein processing, mitochondrial functions, oxidative stress level, and neuroinflammation (Lalla and Donmez, 2013; Jęśko et al., 2017; Lee et al., 2018; Mohamad Nasir et al., 2018; Rizzi and Roriz-Cruz, 2018). Here, APP is linked to Alzheimer disease.