NUCB2 and type 2 diabetes mellitus: A few studies (20, 42, 43) declared the antioxidant function of nesfatin-1; noteworthy, we observed that nesfatin-1levels were significantly correlated with GSH (r = 0.222, P = 0.003) and SOD (r = 0.287, P < 0.001) (refer to the Supplementary Figure), indicating a high probability of nesfatin-1 exerting antioxidative effects in the development of T2DM.