CD4+ T cells and CD4+/CD8+ levels were decreased, and memory function with visuospatial domains was negatively correlated with memory T cells (CD4+ CD45RO+ T cells and CD8+ CD28− T cells), confirming that accelerated immune senescence in SLE patients led to cognitive dysfunction, especially in attention deficit, recall, and visuospatial domains. This evidence concerns the gene CD4 and systemic lupus erythematosus.