BTBD10 and central nervous system cancer: Similarly, BTBD10 protein expression was highest in normal brain tissue (0.58 ± 0.11), intermediate in low-grade glioma tissue (0.35 ± 0.06), and lowest in high-grade glioma tissue (0.16 ± 0.07; P < 0.01 between any two of the three groups, Figure 2).