In recent years, it has been found that Tim3 regulates the proliferation of MM cells through the NF-κB signaling pathway [phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/AKT), mammalian target of rapamycin (mTOR), and NF-κB] [27]. This evidence concerns the gene HAVCR2 and Miyoshi myopathy.