At a molecular level, MM is caused by single or multiple gene mutations, heterotopic, chromosome changes, and other factors and mediated by abnormal chromosome hyper-diploidy, immunoglobulin heavy chain shift, cell cycle gene imbalance, nuclear factor-kappaB (NF-κB) pathway changes, and abnormal DNA methylation patterns [1]. The gene discussed is NFKB1; the disease is Miyoshi myopathy.