We observed that a high CRG score was mainly related to the cell cycle (negative regulation of metaphase–anaphase transition of the cell cycle, G2M checkpoint hallmark, E2F target hallmark), tumor progression (epithelial–mesenchymal transition hallmark, angiogenesis hallmark), and immunity (interferon gamma–mediated signaling pathway, T-cell activation via T-cell receptor contact with antigen bound to the MHC molecule on antigen-presenting cell, inflammatory response hallmark). This evidence concerns the gene HLA-C and neoplasm.