While most of the trials are performed in China and USA, currently a phase I trial, CAR2BRAIN using lentiviral transduced CAR NK92 cells redirected against the human epidermal growth factor 2 (HER2, ErbB2) for treatment of recurrent patients with glioblastoma is conducted in Europe, in Frankfurt, Germany. The gene discussed is ERBB2; the disease is glioblastoma.