CD84hi-MDSCs exhibit more robust T-cell suppression and reactive oxygen species (ROS) production compared with CD84−/lo cells, which suggests that CD84 expression is a robust indicator of MDSC capacity (33), and consistent with the observation that M-MDSCs are more immunosuppressive than G-MDSCs in tumor-bearing mice (46, 47). This evidence concerns the gene CD84 and neoplasm.